Drug repurposing


Repurposing of ibuprofen for treatment of the Ebola disease.

In silico analysis suggests repurposing of ibuprofen for prevention and treatment of EBOLA virus disease.
Veljkovic V, Goeijenbier M, Glisic S, Veljkovic N, Perovic VR, Sencanski M, Branch DR, Paessler S. F1000Res. 2015 May 1;4:104


Virtual screen for repurposing approved and experimental drugs for candidate inhibitors of EBOLA virus infection.
Veljkovic V, Loiseau PM, Figadere B, Glisic S, Veljkovic N, Perovic VR, Cavanaugh DP, Branch DR. F1000Res. 2015;4:34

Improving attrition rates in Ebola virus drug discovery.
Glisic S, Paessler S, Veljkovic N, Perovic VR, Prljic J, Veljkovic V. Expert Opin Drug Discov. 015;10(9):1025.


Inhibition of the cell entry of Ebola virus by binding of ibuprofen to GP experimentally confirmed a year later.

Toremifene interacts with and destabilizes the Ebola virus glycoprotein.
Zhao Y, Ren J, Harlos K, Jones DM, Zeltina A, Bowden TA, Padilla-Parra S, Fry EE, Stuart DI. Nature. 2016 Jul 7;535(7610):169