Protein-protein interactions


By screening of the GeneBank database the vascular proteins EMILIN1 (Elastin Microfibril Interface Located Protein), EMILIN2, MMN1, and MMN2 were identified as anthrax PA antigen interacting molecules. This virtual molecular interaction was formally proven by solid phase assays using recombinant proteins.


EMILINs interact with anthrax protective antigen and inhibit toxin action in vitro.
Doliana R, Veljkovic V, Prljic J, Veljkovic N, De Lorenzo E, Mongiat M, Ligresti G, Marastoni S, Colombatti A. Matrix Biol. 2008 Mar;27(2):96-106.